Jianping Liu
PhD student
Xu Group
Australian Institute of Bioengineering and Nanotechnology (AIBN)
Researcher biography
Recent researches on the cancer treatment have been focused on eliminating primary solid tumours and avoiding tumour recurrence. However it is difficult to improve therapeutic efficiency just with single cancer treatment due to tumour heterogeneity. To overcome the challenge, a novel organic-inorganic hybrid nanocomposite system is developed as co-delivery platform to enhance cancer treatment efficiency and prevent tumour metastasis via the combinational pathway. The successful development of this hybrid nanocomposite system will open a new opportunity to the anticancer combination treatment, providing much-needed hope for patients by greatly increasing the chance of success in cancer therapy.
2017.7- present: PhD candidate in The University of Queensland, Smart organic-inorganic hybrid nanocomposites for cancer combination treatment, under the supervision of Prof Zhi Ping (Gordon) Xu;
2013.9- 2016.6: M.S. in Tianjin University, Acidity-Activatable Polymeric Nanoparticles for Photothermal/Chemotherapy of the Drug Resistant Breast Tumor, under the supervision of Prof Anjie Dong and Prof Yaping Li (State Key Laboratory of Drug Research and Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences);
2009.9- 2013.6: B.S. in Ludong University.
Journal Articles
Liu, Jianping, Li, Li, Zhang, Run and Xu, Zhi Ping (2023). The adjacent effect between Gd(iii) and Cu(ii) in layered double hydroxide nanoparticles synergistically enhances T1-weighted magnetic resonance imaging contrast. Nanoscale Horizons, 8 (2), 279-290. doi: 10.1039/d2nh00478j
Fu, Youxin, Zhang, Xing, Liu, Jianping, Qian, Guangren, Xu, Zhi Ping and Zhang, Run (2022). Fluorescence detection and imaging of intracellular sulphite using a remote light activatable photochromic nanoprobe. Journal of Materials Chemistry B, 10 (17), 3366-3374. doi: 10.1039/d2tb00021k
Liu, Jianping, Liu, Kai, Zhang, Liming, Zhong, Ming, Hong, Tingliang, Zhang, Run, Gao, Yufan, Li, Rui, Xu, Tiefeng and Xu, Zhi Ping (2021). Heat/pH-boosted release of 5-fluorouracil and albumin-bound paclitaxel from Cu-doped layered double hydroxide nanomedicine for synergistical chemo-photo-therapy of breast cancer. Journal of Controlled Release, 335, 49-58. doi: 10.1016/j.jconrel.2021.05.011
Liu, Jianping, Wu, Miaomiao, Zhang, Run and Xu, Zhi Ping (2021). Oxygen‐derived free radicals: production, biological importance, bioimaging, and analytical detection with responsive luminescent nanoprobes. VIEW, 2 (5) 20200139, 20200139. doi: 10.1002/viw.20200139
Feng, Huan, Liu, Jianping, Qaitoon, Ali, Meng, Qingtao, Sultanbawa, Yasmina, Zhang, Zhiqiang, Xu, Zhi Ping and Zhang, Run (2021). Responsive small-molecule luminescence probes for sulfite/bisulfite detection in food samples. TrAC Trends in Analytical Chemistry, 136 116199, 116199. doi: 10.1016/j.trac.2021.116199
Liu, Chaolong, Liu, Jianping, Zhang, Wenzhu, Wang, Yong-Lei, Gao, Xiaona, Song, Bo, Yuan, Jingli and Zhang, Run (2021). A Ruthenium(II) complex-based probe for colorimetric and luminescent detection and imaging of hydrogen sulfide in living cells and organisms. Analytica Chimica Acta, 1145, 114-123. doi: 10.1016/j.aca.2020.11.009
Liu, Jianping, Sun, Luyao, Li, Li, Zhang, Run and Xu, Zhi Ping (2021). Synergistic cancer photochemotherapy via layered double hydroxide-based trimodal nanomedicine at very low therapeutic doses. ACS Applied Materials and Interfaces, 13 (6) acsami.0c23143, 7115-7126. doi: 10.1021/acsami.0c23143
Sun, Luyao, Wang, Jingjing, Liu, Jianping, Li, Li and Xu, Zhi Ping (2021). Creating structural defects of drug‐free copper‐containing layered double hydroxide nanoparticles to synergize photothermal/photodynamic/chemodynamic cancer therapy. Small Structures, 2 (2) 2000112, 2000112. doi: 10.1002/sstr.202000112
Xu, Tiefeng, Liu, Jianping, Sun, Luyao, Zhang, Run, Xu, Zhi Ping and Sun, Qing (2021). Enhancing tumor accumulation and cellular uptake of layered double hydroxide nanoparticles by coating/detaching pH-triggered charge-convertible polymers. ACS Omega, 6 (5), 3822-3830. doi: 10.1021/acsomega.0c05520
Liu, Jianping, Wu, Yilun, Fu, Changkui, Li, Bei, Li, Li, Zhang, Run, Xu, Tiefeng and Xu, Zhi Ping (2020). Charge reversion simultaneously enhances tumor accumulation and cell uptake of layered double hydroxide nanohybrids for effective imaging and therapy. Small, 16 (31) 2002115, e2002115. doi: 10.1002/smll.202002115
Liu, Chaolong, Liu, Jianping, Zhang, Wenzhu, Wang, Yong‐Lei, Liu, Qi, Song, Bo, Yuan, Jingli and Zhang, Run (2020). “Two Birds with One Stone” Ruthenium(II) Complex Probe for Biothiols Discrimination and Detection In Vitro and In Vivo. Advanced Science, 7 (14) 2000458, 2000458. doi: 10.1002/advs.202000458
Wu, Yilun, Liu, Jianping, Movahedi, Fatemeh, Gu, Wenyi, Xu, Tiefeng and Xu, Zhi Ping (2020). Enhanced prevention of breast tumor metastasis by nanoparticle‐delivered vitamin E in combination with interferon‐gamma. Advanced Healthcare Materials, 9 (6) 1901706, 1901706. doi: 10.1002/adhm.201901706
Zhang, Xing, Fu, Youxin, Liu, Jianping, Qian, Guangren, Zhang, Junji, Zhang, Run and Xu, Zhi Ping (2020). A hydrogen peroxide activatable nanoprobe for light-controlled “double-check” multi-colour fluorescence imaging. Nanoscale, 12 (44), 22527-22533. doi: 10.1039/d0nr04881j
Zhang, Wenzhu, Xi, Xiuyan, Wang, Yong-Lei, Du, Zhongbo, Liu, Chaolong, Liu, Jianping, Song, Bo, Yuan, Jingli and Zhang, Run (2020). Responsive ruthenium complex probe for phosphorescence and time-gated luminescence detection of bisulfite. Dalton Transactions, 49 (17), 5531-5538. doi: 10.1039/c9dt04614c
Liu, Jianping, Duan, Chengchen, Zhang, Wenzhu, Ta, Hang Thu, Yuan, Jingli, Zhang, Run and Xu, Zhi Ping (2019). Responsive nanosensor for ratiometric luminescence detection of hydrogen sulfide in inflammatory cancer cells. Analytica Chimica Acta, 1103, 156-163. doi: 10.1016/j.aca.2019.12.056
Liu, Jianping, Zhang, Run and Xu, Zhi Ping (2019). Nanoparticle‐based nanomedicines to promote cancer immunotherapy: recent advances and future directions. Small, 15 (32) 1900262, 1900262. doi: 10.1002/smll.201900262
Feng, Huan, Wang, Yue, Liu, Jianping, Zhang, Zhiqiang, Yang, Xinyi, Chen, Rong, Meng, Qingtao and Zhang, Run (2019). A highly specific fluorescent probe for rapid detection of hypochlorous acid in vivo and in water samples. Journal of Materials Chemistry B, 7 (24), 3909-3916. doi: 10.1039/c9tb00551j
Liu, Chaolong, Zhang, Run, Zhang, Wenzhu, Liu, Jianping, Wang, Yong-Lei, Du, Zhongbo, Song, Bo, Xu, Zhi Ping and Yuan, Jingli (2019). “Dual-key-and-lock” ruthenium complex probe for lysosomal formaldehyde in cancer cells and tumors. Journal of the American Chemical Society, 141 (21) jacs.8b13898, 8462-8472. doi: 10.1021/jacs.8b13898
Du, Zhongbo, Zhang, Run, Song, Bo, Zhang, Wenzhu, Wang, Yong-Lei, Liu, Jianping, Liu, Chaolong, Xu, Zhi Ping and Yuan, Jingli (2018). Iridium(III) complex-based activatable probe for phosphorescent/time-gated luminescent sensing and imaging of cysteine in mitochondria of live cells and animals. Chemistry: A European Journal, 25 (6), 1365-1365. doi: 10.1002/chem.201805079
Han, Qian, Liu, Jianping, Meng, Qingtao, Wang, Yong-Lei, Feng, Huan, Zhang, Zhiqiang, Xu, Zhi Ping and Zhang, Run (2018). Turn-on fluorescence probe for nitric oxide detection and bioimaging in live cells and zebrafish. ACS Sensors, 4 (2) acssensors.8b00776, 309-316. doi: 10.1021/acssensors.8b00776
Wang, Tingting, Wang, Dangge, Liu, Jianping, Feng, Bing, Zhou, Fangyuan, Zhang, Hanwu, Zhou, Lei, Yin, Qi, Zhang, Zhiwen, Cao, Zhonglian, Yu, Haijun and Li, Yaping (2017). Acidity-triggered ligand-presenting nanoparticles to overcome sequential drug delivery barriers to tumors. Nano Letters, 17 (9), 5429-5436. doi: 10.1021/acs.nanolett.7b02031
Feng, Qiang, Liu, Jianping, Li, Xuanyu, Chen, Qinghua, Sun, Jiashu, Shi, Xinghua, Ding, Baoquan, Yu, Haijun, Li, Yaping and Jiang, Xingyu (2017). One-step microfluidic synthesis of nanocomplex with tunable rigidity and acid-switchable surface charge for overcoming drug resistance. Small, 13 (9), 1603109. doi: 10.1002/smll.201603109
Feng, Bing, Zhou, Fangyuan, Xu, Zhiai, Wang, Tingting, Wang, Dangge, Liu, Jianping, Fu, Yuanlei, Yin, Qi, Zhang, Zhiwen, Yu, Haijun and Li, Yaping (2016). Versatile prodrug nanoparticles for acid-triggered precise imaging and organelle-specific combination cancer therapy. Advanced Functional Materials, 26 (41), 7431-7442. doi: 10.1002/adfm.201602963
Zhang, Junying, Liu, Jianping, Zhu, Yingying, Xu, Zhiai, Xu, Jie, Wang, Tingting, Yu, Haijun and Zhang, Wen (2016). Photodynamic micelles for amyloid β degradation and aggregation inhibition. Chemical Communications, 52 (81), 12044-12047. doi: 10.1039/c6cc06175c
Wang, Dangge, Wang, Tingting, Liu, Jianping, Yu, Haijun, Jiao, Shi, Feng, Bing, Zhou, Fangyuan, Fu, Yuanlei, Yin, Qi, Zhang, Pengcheng, Zhang, Zhiwen, Zhou, Zhaocai and Li, Yaping (2016). Acid-activatable versatile micelleplexes for PD-L1 blockade enhanced cancer photodynamic immunotherapy. Nano Letters, 16 (9), 5503-5513. doi: 10.1021/acs.nanolett.6b01994
Liu, Jian-ping, Wang, Ting-ting, Wang, Dang-ge, Dong, An-jie, Li, Ya-ping and Yu, Hai-jun (2016). Smart nanoparticles improve therapy for drug-resistant tumors by overcoming pathophysiological barriers. Acta Pharmacologica Sinica, 38 (1), 1-8. doi: 10.1038/aps.2016.84
Wang, Tingting, Wang, Dangge, Yu, Haijun, Wang, Mingwei, Liu, Jianping, Feng, Bing, Zhou, Fangyuan, Yin, Qi, Zhang, Zhiwen, Huang, Yongzhuo and Li, Yaping (2016). Intracellularly acid-switchable multifunctional micelles for combinational photo/chemotherapy of the drug-resistant tumor. ACS Nano, 10 (3), 3496-3508. doi: 10.1021/acsnano.5b07706
Zhou, Fangyuan, Feng, Bing, Yu, Haijun, Wang, Dangge, Wang, Tingting, Liu, Jianping, Meng, Qingshuo, Wang, Siling, Zhang, Pengcheng, Zhang, Zhiwen and Li, Yaping (2016). Cisplatin prodrug-conjugated gold nanocluster for fluorescence imaging and targeted therapy of the breast cancer. Theranostics, 6 (5), 679-687. doi: 10.7150/thno.14556
Yu, Haijun, Guo, Chengyue, Feng, Bing, Liu, Jianping, Chen, Xianzhi, Wang, Dangge, Teng, Lesheng, Li, Youxin, Yin, Qi, Zhang, Zhiwen and Li, Yaping (2016). Triple-Layered pH-Responsive Micelleplexes Loaded with siRNA and Cisplatin Prodrug for NF-Kappa B Targeted Treatment of Metastatic Breast Cancer. Theranostics, 6 (1), 14-27. doi: 10.7150/thno.13515
Xu, Shuxin, Wang, Weiwei, Li, Xijing, Liu, Jianping, Dong, Anjie and Deng, Liandong (2014). Sustained release of PTX-incorporated nanoparticles synergized by burst release of DOX.HCl from thermosensitive modified PEG/PCL hydrogel to improve anti-tumor efficiency. European Journal of Pharmaceutical Sciences, 62, 267-273. doi: 10.1016/j.ejps.2014.06.002
Lv, Zesheng, Chang, Longlong, Long, Xingwen, Liu, Jianping, Xiang, Yuzhang, Liu, Jinjian, Liu, Jianfeng, Deng, Hongzhang, Deng, Liandong and Dong, Anjie (2014). Thermosensitive in situ hydrogel based on the hybrid of hyaluronic acid and modified PCL/PEG triblock copolymer. Carbohydrate Polymers, 108, 26-33. doi: 10.1016/j.carbpol.2014.03.016
Thesis
Liu, Jianping (2021). Novel Cu-LDH-based nanomedicine for combination cancer therapy. PhD Thesis, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland. doi: 10.14264/76538b2